MOSAIQ™ BY QUOTIENT

KEY FEATURES

MosaiQ was specifically designed to address the challenges of today’s resource-constrained transfusion diagnostics environment.


Many Blood Services have observed a decrease in demand for blood but an increase in required safety measures – with rising costs. MosaiQ aims to increase laboratory efficiencies.

Benefits

The distinct benefits of MosaiQ

Here are a few of the many benefits you can expect with MosaiQ.

Improved clinical decision-making

By facilitating better matching of donor and patient blood, MosaiQ-screened blood products can potentially reduce the incidence of alloimmunization and other adverse reactions.

 

Consolidation of multiple analyzers

The consolidation and standardization of immunohematology and disease screening analyzers translates to numerous advantages for your lab:

  • Reduced need for training on multiple systems for lab staff.
  • The prospect of fewer contracts and vendors to manage.

 

Streamlined inventory management
  • With a targeted microarray shelf life of 6 months, there is potential for more efficient inventory management and consequently less frequent batch acceptance of red cell reagents.
  • RFID tracking of all reagents and microarray magazines allows for improved safety and simplified tracking/management of Microarrays and reagents.

 

Advanced testing capabilities
  • When fully loaded, MosaiQ can test up to 1000 microarrays.
  • With MosaiQ, the first result is delivered in under 35 minutes with subsequent results every 24 seconds afterwards including:

    • Blood grouping
    • Extended phenotyping
    • Antibody detection
    • Exclusion of other clinically significant antibodies
    • Donor disease screening
  • MosaiQ needs less than 2 ml of whole blood to undertake both comprehensive blood grouping and serological disease screening.
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Technology

MosaiQ Microarray: proprietary and advanced microarray technology for blood grouping and donor disease screening

 

  • Each microarray is composed of up to 132 probes processed simultaneously
  • Well-characterized blood grouping reagents or antibodies are utilized
  • Each microarray includes monoclonal antibodies for ABO, Rh and extended antigen typing
  • Each microarray integrates reagent red blood cells for reverse grouping and one step antibody detection/identification

How MosaiQ works

The MosaiQ IH microarray is composed of two glass panels. One panel is used for antigen typing, including ABO/Rh and extended phenotyping, and the second panel is used for antibody detection/identification and reverse typing. The antigen typing panel is comprised of an array of well-characterized blood-grouping antibodies while the antibody detection/identification panel comprises an array of printed red blood cells. All processes are fully automated on the MosaiQ instrument.

Antigen typing process
  1. 3µL of red blood cells are added to the antigen typing panel and mixed with a diluent.
  2. The microarray is gently shaken to ensure even distribution of cells, then incubated.
  3. Antigens on sample red cells bind with the corresponding antibodies (probes) printed on the base of the antigen typing panel.
  4. After incubation, the residual sample is aspirated and the panel is washed.
  5. MosaiQ identifies which probes have bound with the sample and interprets the results accordingly.

 

Antibody detection/identification process
  1. 80µL of plasma/serum is added to the antibody detection panel and mixed with a diluent.
  2. The microarray is gently shaken to ensure even distribution of plasma, then incubated.
  3. Blood group antibodies in the plasma sample (if any) bind with the corresponding antigens present on reagent red blood cells (probes) printed on the base of the antibody detection/identification panel.
  4. After incubation, the residual sample is aspirated and the panel is washed.
  5. A detection reagent is then added to the antibody identification/detection panel. The detection reagent attaches to any antibodies that have bound to the probes.
  6. A series of washes and rinses occur to remove any unbound detection agent.
  7. An enhancement reagent is then added to the antibody detection/identification panel. Following incubation, this reagent visualises the reaction.
  8. MosaiQ identifies which probes have bound with the sample and interprets the results accordingly.
Antigen typing process

The MosaiQ LinQ

Quotient is committed to offering sound technological solutions that will integrate seamlessly into your lab.

Capabilities of MosaiQ LinQ middleware include:

  • Consolidation – Channel up to 15 MosaiQ Instruments through one interface
  • Order management – Keep track of orders as they are placed and received
  • Result management – Hold, edit, accept results
  • QC management – Perform quality control